Autophagosome-Mediated EGFR Down-Regulation Induced by the CK2 Inhibitor Enhances the Efficacy of EGFR-TKI on EGFR-Mutant Lung Cancer Cells with Resistance by T790M

Protein kinase CK2 has diverse functions promoting and maintaining cancer phenotypes. We investigated the effect of CK2 inhibition in lung cancer cells with T790M-mediated resistance to the EGFR-TK inhibitor. Resistant sublines of PC-9 to gefitinib (PC-9/GR) and erlotinib (PC-9/ER) were established...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:PLoS One
Päätekijät: So, Kwang Sup, Kim, Cheol Hyeon, Rho, Jin Kyung, Kim, Sun Ye, Choi, Yun Jung, Song, Joon Seon, Kim, Woo Sung, Choi, Chang Min, Chun, Young Jin, Lee, Jae Cheol
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2014
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259313/
https://ncbi.nlm.nih.gov/pubmed/25486409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0114000
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia