AUY922 Effectively Overcomes MET- and AXL-Mediated Resistance to EGFR-TKI in Lung Cancer Cells

The activation of bypass signals, such as MET and AXL, has been identified as a possible mechanism of EGFR-TKI resistance. Because various oncoproteins depend on HSP90 for maturation and stability, we investigated the effects of AUY922, a newly developed non-geldanamycin class HSP90 inhibitor, in lu...

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Veröffentlicht in:PLoS One
Hauptverfasser: Choi, Yun Jung, Kim, Seon Ye, So, Kwang Sup, Baek, In-Jeoung, Kim, Woo Sung, Choi, Se Hoon, Lee, Jae Cheol, Bivona, Trever G., Rho, Jin Kyung, Choi, Chang-Min
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4363657/
https://ncbi.nlm.nih.gov/pubmed/25780909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119832
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