Autophagosome-Mediated EGFR Down-Regulation Induced by the CK2 Inhibitor Enhances the Efficacy of EGFR-TKI on EGFR-Mutant Lung Cancer Cells with Resistance by T790M

Protein kinase CK2 has diverse functions promoting and maintaining cancer phenotypes. We investigated the effect of CK2 inhibition in lung cancer cells with T790M-mediated resistance to the EGFR-TK inhibitor. Resistant sublines of PC-9 to gefitinib (PC-9/GR) and erlotinib (PC-9/ER) were established...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: So, Kwang Sup, Kim, Cheol Hyeon, Rho, Jin Kyung, Kim, Sun Ye, Choi, Yun Jung, Song, Joon Seon, Kim, Woo Sung, Choi, Chang Min, Chun, Young Jin, Lee, Jae Cheol
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259313/
https://ncbi.nlm.nih.gov/pubmed/25486409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0114000
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