Selective targeting of transforming growth factor-beta1 into TCR/CD28 signalling plasma membrane domains silences T cell activation

TGFβ1 (Transforming Growth Factor-beta1) is a versatile regulator of T cell immune responses. Depending on its context in the immunological environment, TGFβ1 guides T cells toward specific activation programs including T(H)17 and regulatory T cell activities. Moreover, TGFβ signals function in immu...

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Bibliographic Details
Published in:Cell Commun Signal
Main Authors: Harder, Thomas, Guttek, Karina, Philipsen, Lars, Simeoni, Luca, Schraven, Burkhart, Reinhold, Dirk
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258951/
https://ncbi.nlm.nih.gov/pubmed/25482031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-014-0074-6
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