PARP1-driven Poly-ADP-ribosylation Regulates BRCA1 Function in Homologous Recombination Mediated DNA Repair

BRCA1 promotes homologous recombination-mediated DNA repair (HRR). However, HRR must be tightly regulated to prevent illegitimate recombination. We previously found that BRCA1 HRR function is regulated by the RAP80 complex, but the mechanism was unclear. We have now observed that PARP1 interacts wit...

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Detaylı Bibliyografya
Yayımlandı:Cancer Discov
Asıl Yazarlar: Hu, Yiduo, Petit, Sarah A., Ficarro, Scott B., Toomire, Kimberly J., Xie, Anyong, Lim, Elgene, Cao, Shiliang A., Park, Eunyoung, Eck, Michael J., Scully, Ralph, Brown, Myles, Marto, Jarrod A., Livingston, David M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258125/
https://ncbi.nlm.nih.gov/pubmed/25252691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0891
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