PARP1-driven Poly-ADP-ribosylation Regulates BRCA1 Function in Homologous Recombination Mediated DNA Repair

BRCA1 promotes homologous recombination-mediated DNA repair (HRR). However, HRR must be tightly regulated to prevent illegitimate recombination. We previously found that BRCA1 HRR function is regulated by the RAP80 complex, but the mechanism was unclear. We have now observed that PARP1 interacts wit...

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Detalhes bibliográficos
Publicado no:Cancer Discov
Main Authors: Hu, Yiduo, Petit, Sarah A., Ficarro, Scott B., Toomire, Kimberly J., Xie, Anyong, Lim, Elgene, Cao, Shiliang A., Park, Eunyoung, Eck, Michael J., Scully, Ralph, Brown, Myles, Marto, Jarrod A., Livingston, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258125/
https://ncbi.nlm.nih.gov/pubmed/25252691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0891
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