Targeting α4β7 integrin reduces mucosal transmission of SIV and protects GALT from infection

α4β7 integrin expressing CD4(+) T cells preferentially traffic to gut-associated lymphoid tissues (GALT) and play a key role in HIV/SIV pathogenesis. The administration of an anti-α4β7 monoclonal antibody during acute infection protects macaques from transmission following repeated low-dose intra-va...

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Foilsithe in:Nat Med
Main Authors: Byrareddy, Siddappa N., Kallam, Brianne, Arthos, James, Cicala, Claudia, Nawaz, Fatima, Hiatt, Joseph, Kersh, Ellen N., McNicholl, Janet M., Hanson, Debra, Reimann, Keith A., Brameier, Markus, Walter, Lutz, Rogers, Kenneth, Mayne, Ann E., Dunbar, Paul, Villinger, Tara, Little, Dawn, Parslow, Tristram G., Santangelo, Philip J., Villinger, Francois, Fauci, Anthony S., Ansari, Aftab A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2014
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4257865/
https://ncbi.nlm.nih.gov/pubmed/25419708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3715
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