In Vivo Administration of a JAK3 Inhibitor during Acute SIV Infection Leads to Significant Increases in Viral Load during Chronic Infection

The studies reported herein are the first to document the effect of the in vivo administration of a JAK3 inhibitor for defining the potential role of NK cells during acute SIV infection of a group of 15 rhesus macaques (RM). An additional group of 16 MHC/KIR typed RM was included as controls. The pr...

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Hauptverfasser: Takahashi, Yoshiaki, Byrareddy, Siddappa N., Albrecht, Christina, Brameier, Markus, Walter, Lutz, Mayne, Ann E., Dunbar, Paul, Russo, Robert, Little, Dawn M., Villinger, Tara, Khowawisetsut, Ladawan, Pattanapanyasat, Kovit, Villinger, Francois, Ansari, Aftab A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946395/
https://ncbi.nlm.nih.gov/pubmed/24603870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003929
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