Targeting α4β7 integrin reduces mucosal transmission of SIV and protects GALT from infection

α4β7 integrin expressing CD4(+) T cells preferentially traffic to gut-associated lymphoid tissues (GALT) and play a key role in HIV/SIV pathogenesis. The administration of an anti-α4β7 monoclonal antibody during acute infection protects macaques from transmission following repeated low-dose intra-va...

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Pubblicato in:Nat Med
Autori principali: Byrareddy, Siddappa N., Kallam, Brianne, Arthos, James, Cicala, Claudia, Nawaz, Fatima, Hiatt, Joseph, Kersh, Ellen N., McNicholl, Janet M., Hanson, Debra, Reimann, Keith A., Brameier, Markus, Walter, Lutz, Rogers, Kenneth, Mayne, Ann E., Dunbar, Paul, Villinger, Tara, Little, Dawn, Parslow, Tristram G., Santangelo, Philip J., Villinger, Francois, Fauci, Anthony S., Ansari, Aftab A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4257865/
https://ncbi.nlm.nih.gov/pubmed/25419708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3715
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