KCNJ2 Mutation Causes an Adrenergic-Dependent Rectification Abnormality with Calcium Sensitivity and Ventricular Arrhythmia

BACKGROUND: KCNJ2 mutations are associated with a variety of inherited arrhythmia syndromes including CPVT3. OBJECTIVE: Detailed cellular and mechanistic characterization of the clinically recognized KCNJ2 mutation R67Q. METHODS: Kir2.1 current density was measured using the whole-cell voltage clamp...

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Publicado en:Heart Rhythm
Main Authors: Kalscheur, Matthew M., Vaidyanathan, Ravi, Orland, Kate M., Abozeid, Sara, Fabry, Nicholas, Maginot, Kathleen R., January, Craig T., Makielski, Jonathan C., Eckhardt, Lee L.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4257478/
https://ncbi.nlm.nih.gov/pubmed/24561538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2014.02.015
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