I(K1)-enhanced human-induced pluripotent stem cell-derived cardiomyocytes: an improved cardiomyocyte model to investigate inherited arrhythmia syndromes

Currently available induced pluripotent stem cell-derived cardiomyocytes (iPS-CMs) do not ideally model cellular mechanisms of human arrhythmic disease due to lack of a mature action potential (AP) phenotype. In this study, we create and characterize iPS-CMs with an electrically mature AP induced by...

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Veröffentlicht in:Am J Physiol Heart Circ Physiol
Hauptverfasser: Vaidyanathan, Ravi, Markandeya, Yogananda S., Kamp, Timothy J., Makielski, Jonathan C., January, Craig T., Eckhardt, Lee L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935522/
https://ncbi.nlm.nih.gov/pubmed/27059077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00481.2015
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