Opposing mechanisms of regulation of a G-protein-coupled inward rectifier K+ channel in rat brain neurons.

In locus coeruleus neurons, substance P (SP) suppresses an inwardly rectifying K+ current via a pertussis toxin-insensitive guanine nucleotide binding protein (G protein; GnonPTX), whereas somatostatin (SOM) or [Met]enkephalin (MENK) enhances it via a pertussis toxin-sensitive G protein (GPTX). The...

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Bibliografiske detaljer
Main Authors: Velimirovic, B M, Koyano, K, Nakajima, S, Nakajima, Y
Format: Artigo
Sprog:Inglês
Udgivet: 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC42565/
https://ncbi.nlm.nih.gov/pubmed/7533296
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