Inhibiting Heat Shock Protein 90 (HSP90) Limits the Formation of Liver Cysts Induced by Conditional Deletion of Pkd1 in Mice

Polycystic liver disease (PLD) occurs in 75–90% of patients affected by autosomal dominant polycystic kidney disease (ADPKD), which affects 1∶400–1,000 adults and arises from inherited mutations in the PKD1 or PKD2 genes. PLD can lead to bile duct obstructions, infected or bleeding cysts, and hepato...

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Publicat a:PLoS One
Autors principals: Smithline, Zachary B., Nikonova, Anna S., Hensley, Harvey H., Cai, Kathy Q., Egleston, Brian L., Proia, David A., Seeger-Nukpezah, Tamina, Golemis, Erica A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256400/
https://ncbi.nlm.nih.gov/pubmed/25474361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0114403
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