Inhibiting the HSP90 chaperone slows cyst growth in a mouse model of autosomal dominant polycystic kidney disease

Autosomal dominant polycystic kidney disease (ADPKD) is a progressive genetic syndrome with an incidence of 1:500 in the population, arising from inherited mutations in the genes for polycystic kidney disease 1 (PKD1) or polycystic kidney disease 2 (PKD2). Typical onset is in middle age, with gradua...

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Autori principali: Seeger-Nukpezah, Tamina, Proia, David A., Egleston, Brian L., Nikonova, Anna S., Kent, Tatiana, Cai, Kathy Q., Hensley, Harvey H., Ying, Weiwen, Chimmanamada, Dinesh, Serebriiskii, Ilya G., Golemis, Erica A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2013
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3732984/
https://ncbi.nlm.nih.gov/pubmed/23858461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1301904110
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