Opposing Effects of Inhibitors of Aurora-A and EGFR in Autosomal-Dominant Polycystic Kidney Disease

Aurora-A kinase (AURKA) overexpression in numerous tumors induces aneuploidy, in part because of cytokinetic defects. Alisertib and other small-molecule inhibitors targeting AURKA are effective in some patients as monotherapies or combination therapies. Epidermal growth factor receptor (EGFR) pro-pr...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Nikonova, Anna S., Deneka, Alexander Y., Eckman, Louisa, Kopp, Meghan C., Hensley, Harvey H., Egleston, Brian L., Golemis, Erica A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607875/
https://ncbi.nlm.nih.gov/pubmed/26528438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2015.00228
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