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Dissection of Hexosyl- and Sialyltransferase Domains in the Bifunctional Capsule Polymerases from Neisseria meningitidis W and Y Defines a New Sialyltransferase Family
Crucial virulence determinants of disease causing Neisseria meningitidis species are their extracellular polysaccharide capsules. In the serogroups W and Y, these are heteropolymers of the repeating units (→6)-α-d-Gal-(1→4)-α-Neu5Ac-(2→)(n) in NmW and (→6)-α-d-Glc-(1→4)-α-Neu5Ac-(2→)(n) in NmY. The...
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| 發表在: | J Biol Chem |
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| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4256332/ https://ncbi.nlm.nih.gov/pubmed/25342753 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.597773 |
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