Dissection of Hexosyl- and Sialyltransferase Domains in the Bifunctional Capsule Polymerases from Neisseria meningitidis W and Y Defines a New Sialyltransferase Family

Crucial virulence determinants of disease causing Neisseria meningitidis species are their extracellular polysaccharide capsules. In the serogroups W and Y, these are heteropolymers of the repeating units (→6)-α-d-Gal-(1→4)-α-Neu5Ac-(2→)(n) in NmW and (→6)-α-d-Glc-(1→4)-α-Neu5Ac-(2→)(n) in NmY. The...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Romanow, Angela, Keys, Timothy G., Stummeyer, Katharina, Freiberger, Friedrich, Henrissat, Bernard, Gerardy-Schahn, Rita
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Glycobiology and Extracellular Matrices
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256332/
https://ncbi.nlm.nih.gov/pubmed/25342753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.597773
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