FBXO22 Protein Is Required for Optimal Synthesis of the N-Methyl-d-Aspartate (NMDA) Receptor Coagonist d-Serine

d-Serine is a physiological activator of NMDA receptors (NMDARs) in the nervous system that mediates several NMDAR-mediated processes ranging from normal neurotransmission to neurodegeneration. d-Serine is synthesized from l-serine by serine racemase (SR), a brain-enriched enzyme. However, little is...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Dikopoltsev, Elena, Foltyn, Veronika N., Zehl, Martin, Jensen, Ole N., Mori, Hisashi, Radzishevsky, Inna, Wolosker, Herman
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256329/
https://ncbi.nlm.nih.gov/pubmed/25336657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.618405
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