Effects of Neonatal Enzyme Replacement Therapy and Simvastatin Treatment on Cervical Spine Disease in Mucopolysaccharidosis I Dogs

Mucopolysaccharidosis I (MPS I) is a lysosomal storage disease characterized by deficient α-L-iduronidase activity, leading to the accumulation of poorly degraded glycosaminoglycans (GAGs). Children with MPS I exhibit high incidence of spine disease, including accelerated disc degeneration and verte...

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Bibliographic Details
Published in:J Bone Miner Res
Main Authors: Chiaro, Joseph A, O’Donnell, Patricia, Shore, Eileen M, Malhotra, Neil R, Ponder, Katherine P, Haskins, Mark E, Smith, Lachlan J
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256138/
https://ncbi.nlm.nih.gov/pubmed/24898323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2290
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