Crystal Structures of Ligand-Bound Octaprenyl Pyrophosphate Synthase from Escherichia coli Reveal the Catalytic and Chain-Length Determining Mechanisms()

Octaprenyl pyrophosphate synthase (OPPs) catalyzes consecutive condensation reactions of one allylic substrate farnesyl pyrophosphate (FPP) and five homoallylic substrate isopentenyl pyrophosphate (IPP) molecules to form a C(40) long-chain product OPP, which serves as a side chain of ubiquinone and...

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Detalhes bibliográficos
Publicado no:Proteins
Main Authors: Han, Xu, Chen, Chun-Chi, Kuo, Chih-Jung, Huang, Chun-Hsiang, Zheng, Yingying, Ko, Tzu-Ping, Zhu, Zhen, Feng, Xinxin, Wang, Ke, Oldfield, Eric, Wang, Andrew H.-J., Liang, Po-Huang, Guo, Rey-Ting, Ma, Yanhe
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256133/
https://ncbi.nlm.nih.gov/pubmed/24895191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24618
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