Structure-Based Inhibitors Exhibit Differential Activities against Helicobacter pylori and Escherichia coli Undecaprenyl Pyrophosphate Synthases

Helicobacter pylori colonizes the human gastric epithelium and causes diseases such as gastritis, peptic ulcers, and stomach cancer. Undecaprenyl pyrophosphate synthase (UPPS), which catalyzes consecutive condensation reactions of farnesyl pyrophosphate with eight isopentenyl pyrophosphate to form l...

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Détails bibliographiques
Auteurs principaux: Kuo, Chih-Jung, Guo, Rey-Ting, Lu, I-Lin, Liu, Hun-Ge, Wu, Su-Ying, Ko, Tzu-Ping, Wang, Andrew H.-J., Liang, Po-Huang
Format: Artigo
Langue:Inglês
Publié: Hindawi Publishing Corporation 2008
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276626/
https://ncbi.nlm.nih.gov/pubmed/18382620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2008/841312
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