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Molecular Dynamics Study of the Opening Mechanism for DNA Polymerase I
During DNA replication, DNA polymerases follow an induced fit mechanism in order to rapidly distinguish between correct and incorrect dNTP substrates. The dynamics of this process are crucial to the overall effectiveness of catalysis. Although X-ray crystal structures of DNA polymerase I with substr...
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| 發表在: | PLoS Comput Biol |
|---|---|
| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Public Library of Science
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4256020/ https://ncbi.nlm.nih.gov/pubmed/25474643 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003961 |
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