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Non-Canonical Notch Signaling in Cancer and Immunity

Canonical Notch signaling is initiated by γ-secretase-mediated cleavage of the Notch receptor, leading to the release of the active intra-cellular domain of Notch that migrates to the nucleus and interacts with RBP-Jκ, resulting in the activation of downstream target genes. While canonical Notch sig...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Ayaz, Furkan, Osborne, Barbara A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255497/
https://ncbi.nlm.nih.gov/pubmed/25538890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2014.00345
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