Spatially Defined EGF Receptor Activation Reveals an F-Actin-Dependent Phospho-Erk Signaling Complex

We investigated the association of signaling proteins with epidermal growth factor (EGF) receptors (EGFR) using biotinylated EGF bound to streptavidin that is covalently coupled in an ordered array of micron-sized features on silicon surfaces. Using NIH-3T3 cells stably expressing EGFR, we observe c...

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Foilsithe in:Biophys J
Main Authors: Singhai, Amit, Wakefield, Devin L., Bryant, Kirsten L., Hammes, Stephen R., Holowka, David, Baird, Barbara
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Biophysical Society 2014
Ábhair:
Cell Biophysics
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255200/
https://ncbi.nlm.nih.gov/pubmed/25468343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.09.048
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