Spatially Defined EGF Receptor Activation Reveals an F-Actin-Dependent Phospho-Erk Signaling Complex

We investigated the association of signaling proteins with epidermal growth factor (EGF) receptors (EGFR) using biotinylated EGF bound to streptavidin that is covalently coupled in an ordered array of micron-sized features on silicon surfaces. Using NIH-3T3 cells stably expressing EGFR, we observe c...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Singhai, Amit, Wakefield, Devin L., Bryant, Kirsten L., Hammes, Stephen R., Holowka, David, Baird, Barbara
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2014
Assuntos:
Cell Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255200/
https://ncbi.nlm.nih.gov/pubmed/25468343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.09.048
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