Structure-Guided Functional Characterization of DUF1460 Reveals a New, Highly Specific NlpC/P60 Amidase Family

GlcNAc-1,6-anhydro-MurNAc-tetrapeptide is a major peptidoglycan degradation intermediate and a cytotoxin. It is generated by lytic transglycosylases and further degraded and recycled by various enzymes. We have identified and characterized a novel, highly specific N-acetylmuramoyl-L-alanine amidase...

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Published in:Structure
Main Authors: Xu, Qingping, Mengin-Lecreulx, Dominique, Patin, Delphine, Grant, Joanna C., Chiu, Hsiu-Ju, Jaroszewski, Lukasz, Knuth, Mark W., Godzik, Adam, Lesley, Scott A., Elsliger, Marc-André, Deacon, Ashley M., Wilson, Ian A.
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255150/
https://ncbi.nlm.nih.gov/pubmed/25465128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2014.09.018
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