Antiviral Interferon-Beta Signaling Induced by Designed Transcription Activator-Like Effectors (TALE)

Here we show that designed transcription activator-like effectors (TALEs) that bind to defined areas of the interferon beta promoter are capable to induce IFN-beta expression and signaling in human cells. Importantly, TALE-mediated IFN-beta signaling occurs independently of pathogen pattern recognit...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Renner, Ivonne, Funk, Nancy, Geissler, Rene, Friedrich, Susann, Penzel, Anika, Behrens, Sven-Erik
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255017/
https://ncbi.nlm.nih.gov/pubmed/25470486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0114288
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