An acute rise in intraluminal pressure shifts the mediator of flow-mediated dilation from nitric oxide to hydrogen peroxide in human arterioles

Endothelial nitric oxide (NO) is the primary mediator of flow-mediated dilation (FMD) in human adipose microvessels. Impaired NO-mediated vasodilation occurs after acute and chronic hypertension, possibly due to excess generation of reactive oxygen species (ROS). The direct role of pressure elevatio...

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Bibliografische gegevens
Gepubliceerd in:Am J Physiol Heart Circ Physiol
Hoofdauteurs: Beyer, Andreas M., Durand, Matthew J., Hockenberry, Joseph, Gamblin, T. Clark, Phillips, Shane A., Gutterman, David D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Physiological Society 2014
Onderwerpen:
Vascular Biology and Microcirculation
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255007/
https://ncbi.nlm.nih.gov/pubmed/25260615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00557.2014
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