Ceramide Changes the Mediator of Flow-Induced Vasodilation from Nitric Oxide to Hydrogen Peroxide in the Human Microcirculation

RATIONALE: Mitochondrial-derived hydrogen peroxide (H(2)O(2)) regulates flow-induced dilation (FID) in microvessels from patients with coronary artery disease (CAD). The relationship between ceramide, an independent risk factor for CAD and a known inducer of mitochondrial reactive oxygen species (RO...

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Udgivet i:Circ Res
Main Authors: Freed, Julie K., Beyer, Andreas M., LoGiudice, John A, Hockenberry, Joseph C., Gutterman, David D.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640193/
https://ncbi.nlm.nih.gov/pubmed/24920698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.115.303881
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