Decationized polyplexes as stable and safe carrier systems for improved biodistribution in systemic gene therapy

Many polycation-based gene delivery vectors show high transfection in vitro, but their cationic nature generally leads to significant toxicity and poor in vivo performance which significantly hampers their clinical applicability. Unlike conventional polycation-based systems, decationized polyplexes...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:J Control Release
Main Authors: Novo, Luís, Rizzo, Larissa Y., Golombek, Susanne K., Dakwar, George R., Lou, Bo, Remaut, Katrien, Mastrobattista, Enrico, van Nostrum, Cornelus F., Jahnen-Dechent, Wilhelm, Kiessling, Fabian, Braeckmans, Kevin, Lammers, Twan, Hennink, Wim E.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4254847/
https://ncbi.nlm.nih.gov/pubmed/25204289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2014.08.028
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker