Decationized polyplexes as stable and safe carrier systems for improved biodistribution in systemic gene therapy

Many polycation-based gene delivery vectors show high transfection in vitro, but their cationic nature generally leads to significant toxicity and poor in vivo performance which significantly hampers their clinical applicability. Unlike conventional polycation-based systems, decationized polyplexes...

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Vydáno v:J Control Release
Hlavní autoři: Novo, Luís, Rizzo, Larissa Y., Golombek, Susanne K., Dakwar, George R., Lou, Bo, Remaut, Katrien, Mastrobattista, Enrico, van Nostrum, Cornelus F., Jahnen-Dechent, Wilhelm, Kiessling, Fabian, Braeckmans, Kevin, Lammers, Twan, Hennink, Wim E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4254847/
https://ncbi.nlm.nih.gov/pubmed/25204289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2014.08.028
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