Decationized polyplexes as stable and safe carrier systems for improved biodistribution in systemic gene therapy

Many polycation-based gene delivery vectors show high transfection in vitro, but their cationic nature generally leads to significant toxicity and poor in vivo performance which significantly hampers their clinical applicability. Unlike conventional polycation-based systems, decationized polyplexes...

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Xehetasun bibliografikoak
Argitaratua izan da:J Control Release
Egile Nagusiak: Novo, Luís, Rizzo, Larissa Y., Golombek, Susanne K., Dakwar, George R., Lou, Bo, Remaut, Katrien, Mastrobattista, Enrico, van Nostrum, Cornelus F., Jahnen-Dechent, Wilhelm, Kiessling, Fabian, Braeckmans, Kevin, Lammers, Twan, Hennink, Wim E.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2014
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4254847/
https://ncbi.nlm.nih.gov/pubmed/25204289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2014.08.028
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