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Molecular Basis of the Clotting Defect in a Bleeding Patient Missing the Asp-185 Codon in the Factor X Gene
Factor X (FX) is a vitamin K-dependent plasma zymogen, which following activation to factor Xa (FXa), converts prothrombin to thrombin in the blood clotting cascade. It was recently demonstrated that a natural variant of FX carrying the Asp-185 deletion (FX-D185del, chymotrypsinogen numbering) was a...
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| Publicado no: | Thromb Res |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4254040/ https://ncbi.nlm.nih.gov/pubmed/25179519 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.thromres.2014.08.004 |
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