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Expanding the results of a high throughput screen against an isochorismate-pyruvate lyase to enzymes of a similar scaffold or mechanism

Antibiotic resistance is a growing health concern, and new avenues of antimicrobial drug design are being actively sought. One suggested pathway to be targeted for inhibitor design is that of iron scavenging through siderophores. Here we present a high throughput screen to the isochorismate-pyruvate...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Bioorg Med Chem
Κύριοι συγγραφείς: Meneely, Kathleen M., Luo, Qianyi, Riley, Andrew P., Taylor, Byron, Roy, Anuradha, Stein, Ross L., Prisinzano, Thomas E., Lamb, Audrey L.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2014
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4254016/
https://ncbi.nlm.nih.gov/pubmed/25282647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.09.010
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