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Expanding the results of a high throughput screen against an isochorismate-pyruvate lyase to enzymes of a similar scaffold or mechanism

Antibiotic resistance is a growing health concern, and new avenues of antimicrobial drug design are being actively sought. One suggested pathway to be targeted for inhibitor design is that of iron scavenging through siderophores. Here we present a high throughput screen to the isochorismate-pyruvate...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Meneely, Kathleen M., Luo, Qianyi, Riley, Andrew P., Taylor, Byron, Roy, Anuradha, Stein, Ross L., Prisinzano, Thomas E., Lamb, Audrey L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4254016/
https://ncbi.nlm.nih.gov/pubmed/25282647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.09.010
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