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Nucleic acid induced unfolding of recombinant prion protein globular fragment is pH dependent
Nucleic acid can catalyze the conversion of α-helical cellular prion protein to β-sheet rich Proteinase K resistant prion protein oligomers and amyloid polymers in vitro and in solution. Because unfolding of a protein molecule from its ordered α-helical structure is considered to be a necessary step...
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| Vydáno v: | Protein Sci |
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| Hlavní autoři: | , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
BlackWell Publishing Ltd
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4253818/ https://ncbi.nlm.nih.gov/pubmed/25271002 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2573 |
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