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Nucleic acid induced unfolding of recombinant prion protein globular fragment is pH dependent

Nucleic acid can catalyze the conversion of α-helical cellular prion protein to β-sheet rich Proteinase K resistant prion protein oligomers and amyloid polymers in vitro and in solution. Because unfolding of a protein molecule from its ordered α-helical structure is considered to be a necessary step...

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Bibliografiske detaljer
Udgivet i:Protein Sci
Main Authors: Bera, Alakesh, Nandi, Pradip K
Format: Artigo
Sprog:Inglês
Udgivet: BlackWell Publishing Ltd 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253818/
https://ncbi.nlm.nih.gov/pubmed/25271002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2573
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