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Structure of a partially unfolded form of Escherichia coli dihydrofolate reductase provides insight into its folding pathway

Proteins frequently fold via folding intermediates that correspond to local minima on the conformational energy landscape. Probing the structure of the partially unfolded forms in equilibrium under native conditions can provide insight into the properties of folding intermediates. To elucidate the s...

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Detalles Bibliográficos
Publicado en:Protein Sci
Main Authors: Kasper, Joseph R, Liu, Pei-Fen, Park, Chiwook
Formato: Artigo
Idioma:Inglês
Publicado: BlackWell Publishing Ltd 2014
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253813/
https://ncbi.nlm.nih.gov/pubmed/25252157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2555
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