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Redox regulation of botulinum neurotoxin toxicity: therapeutic implications

Botulinum neurotoxin causes botulism, and the only effective antidote is the antitoxin. Botulinum neurotoxins are disulfide linked di-chain proteins encompassing a light chain Zn(2+)-protease that is translocated by a heavy chain channel from the synaptic vesicle lumen into the neuronal cytosol wher...

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Dades bibliogràfiques
Publicat a:Trends Mol Med
Autor principal: Montal, Mauricio
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253726/
https://ncbi.nlm.nih.gov/pubmed/25242227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmed.2014.09.005
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