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Removal of a small C-terminal region of JCV and SV40 large T antigens has differential effects on transformation
The large T antigen (LT) protein of JCV and SV40 polyomaviruses is required to induce tumors in rodents and transform cells in culture. When both LTs are compared side-by-side in cell culture assays, SV40 shows a more robust transformation phenotype even though the LT sequences are highly conserved....
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| Publicat a: | Virology |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4253650/ https://ncbi.nlm.nih.gov/pubmed/25129438 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2014.07.038 |
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