Hedgehog signaling drives radioresistance and stroma-driven tumor repopulation in head and neck squamous cancers

Local control and overall survival in patients with advanced head and neck squamous cell cancer (HNSCC) remains dismal. Signaling through the Hedgehog (Hh) pathway is associated with epithelial-to-mesenchymal transition (EMT) and activation of the Hh effector transcription factor Gli1 is a poor prog...

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Pubblicato in:Cancer Res
Autori principali: Gan, Gregory N., Eagles, Justin, Keysar, Stephen B., Wang, Guoliang, Glogowska, Magdalena J., Altunbas, Cem, Anderson, Ryan T., Le, Phuong N., Morton, J. Jason, Frederick, Barbara, Raben, David, Wang, Xiao-Jing, Jimeno, Antonio
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253591/
https://ncbi.nlm.nih.gov/pubmed/25297633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-1346
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