Nonenzymatic glycation of human lens crystallin. Effect of aging and diabetes mellitus.

We have examined the nonenzymatic glycation of human lens crystallin, an extremely long-lived protein, from 16 normal human ocular lenses 0.2-99 yr of age, and from 11 diabetic lenses 52-82-yr-old. The glucitol-lysine (Glc-Lys) content of soluble and insoluble crystallin was determined after reducti...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Garlick, R L, Mazer, J S, Chylack, L T, Tung, W H, Bunn, H F
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 1984
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC425353/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6438156/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI111592
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