Interleukin-4 up-regulation of epidermal interleukin-19 expression in keratinocytes involves the binding of signal transducer and activator of transcription 6 (Stat6) to the imperfect Stat6 sites

Interleukin-19 (IL-19) plays an important role in asthma by stimulating T helper type 2 (Th2) cytokine production. Interestingly, IL-4, a key Th2 cytokine, in turn up-regulates IL-19 expression in bronchial epithelial cells, so forming a positive feedback loop. In atopic dermatitis (AD), another Th2...

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Bibliografische gegevens
Gepubliceerd in:Immunology
Hoofdauteurs: Bao, Lei, Alexander, Jaime B, Shi, Vivian Y, Mohan, Girish C, Chan, Lawrence S
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BlackWell Publishing Ltd 2014
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Original Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253508/
https://ncbi.nlm.nih.gov/pubmed/24943510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12339
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