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Iro/IRX transcription factors negatively regulate Dpp/TGF-β pathway activity during intestinal tumorigenesis
Activating mutations in Wnt and EGFR/Ras signaling pathways are common in colorectal cancer (CRC). Remarkably, clonal co-activation of these pathways in the adult Drosophila midgut induces “tumor-like” overgrowths. Here, we show that, in these clones and in CRC cell lines, Dpp/TGF-β acts as a tumor...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | EMBO Rep |
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| Κύριοι συγγραφείς: | , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
BlackWell Publishing Ltd
2014
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4253495/ https://ncbi.nlm.nih.gov/pubmed/25296644 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201438622 |
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