Iro/IRX transcription factors negatively regulate Dpp/TGF-β pathway activity during intestinal tumorigenesis

Activating mutations in Wnt and EGFR/Ras signaling pathways are common in colorectal cancer (CRC). Remarkably, clonal co-activation of these pathways in the adult Drosophila midgut induces “tumor-like” overgrowths. Here, we show that, in these clones and in CRC cell lines, Dpp/TGF-β acts as a tumor...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Martorell, Òscar, Barriga, Francisco M, Merlos-Suárez, Anna, Stephan-Otto Attolini, Camille, Casanova, Jordi, Batlle, Eduard, Sancho, Elena, Casali, Andreu
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253495/
https://ncbi.nlm.nih.gov/pubmed/25296644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201438622
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