GUCY2C lysosomotropic endocytosis delivers immunotoxin therapy to metastatic colorectal cancer

The emergence of targeted cancer therapy has been limited by the paucity of determinants which are tumor-specific and generally associated with disease, and have cell dynamics which effectively deploy cytotoxic payloads. Guanylyl cyclase C (GUCY2C) may be ideal for targeting because it is normally e...

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Опубликовано в: :Oncotarget
Главные авторы: Marszalowicz, Glen P., Snook, Adam E., Magee, Michael S., Merlino, Dante, Lisa, D. Berman-Booty, Waldman, Scott A.
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2014
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253446/
https://ncbi.nlm.nih.gov/pubmed/25294806
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