MUC1-C confers EMT and KRAS independence in mutant KRAS lung cancer cells

Non-small cell lung cancers (NSCLCs) that harbor an oncogenic KRAS mutation are often associated with resistance to targeted therapies. The MUC1-C transmembrane protein is aberrantly overexpressed in NSCLCs and confers a poor outcome; however, the functional role for MUC1-C in mutant KRAS NSCLC cell...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Kharbanda, Akriti, Rajabi, Hasan, Jin, Caining, Alam, Maroof, Wong, Kwok-Kin, Kufe, Donald
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2014
Sujets:
Priority Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253405/
https://ncbi.nlm.nih.gov/pubmed/25245423
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