Hypoxia-inducible factors enhance glutamate signaling in cancer cells

Signaling through glutamate receptors has been reported in human cancers, but the molecular mechanisms are not fully delineated. We report that in hepatocellular carcinoma and clear cell renal carcinoma cells, increased activity of hypoxia-inducible factors (HIFs) due to hypoxia or VHL loss-of-funct...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Hu, Hongxia, Takano, Naoharu, Xiang, Lisha, Gilkes, Daniele M., Luo, Weibo, Semenza, Gregg L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2014
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Priority Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253402/
https://ncbi.nlm.nih.gov/pubmed/25326682
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