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Insulin receptor degradation is accelerated in cultured lymphocytes from patients with genetic syndromes of extreme insulin resistance.

Previous studies of the insulin receptor in disease states have utilized primarily techniques of equilibrium binding and, to a limited extent structural, analysis. Though techniques have been developed to study receptor degradation in normal cells, they have not been applied to disease states. In th...

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Udgivet i:J Clin Invest
Principais autores: McElduff, A, Hedo, J A, Taylor, S I, Roth, J, Gorden, P
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1984
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC425304/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6480829/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI111547
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