A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity

Intracellular inclusions composed of hyperphosphorylated filamentous tau are a hallmark of Alzheimer’s disease, progressive supranuclear palsy, Pick’s disease and other sporadic neurodegenerative tauopathies. Recent in vitro and in vivo studies have shown that tau aggregates do not only seed further...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Main Authors: Ahmed, Zeshan, Cooper, Jane, Murray, Tracey K., Garn, Katya, McNaughton, Emily, Clarke, Hannah, Parhizkar, Samira, Ward, Mark A., Cavallini, Annalisa, Jackson, Samuel, Bose, Suchira, Clavaguera, Florence, Tolnay, Markus, Lavenir, Isabelle, Goedert, Michel, Hutton, Michael L., O’Neill, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2014
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4252866/
https://ncbi.nlm.nih.gov/pubmed/24531916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-014-1254-6
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