Rapid Neurofibrillary Tangle Formation after Localized Gene Transfer of Mutated Tau

Neurofibrillary pathology was produced in the brains of adult rats after localized gene transfer of human tau carrying the P301L mutation, which is associated with frontotemporal dementia with parkinsonism. Within 1 month of in situ transfection of the basal forebrain region of normal rats, tau-immu...

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Detalhes bibliográficos
Main Authors: Klein, Ronald L., Lin, Wen-Lang, Dickson, Dennis W., Lewis, Jada, Hutton, Michael, Duff, Karen, Meyer, Edwin M., King, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2004
Assuntos:
Animal Model
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1602230/
https://ncbi.nlm.nih.gov/pubmed/14695347
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