Myocardial Drug Distribution Generated from Local Epicardial Application: Potential Impact of Cardiac Capillary Perfusion in a Swine Model Using Epinephrine

Prior studies in small mammals have shown that local epicardial application of inotropic compounds drives myocardial contractility without systemic side effects. Myocardial capillary blood flow, however, may be more significant in larger species than in small animals. We hypothesized that bulk perfu...

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Detalhes bibliográficos
Publicado no:J Control Release
Main Authors: Maslov, Mikhail Y., Edelman, Elazer R., Pezone, Matthew J., Wei, Abraham E., Wakim, Matthew G., Murray, Michael R., Tsukada, Hisashi, Gerogiannis, Iraklis S., Groothuis, Adam, Lovich, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4252373/
https://ncbi.nlm.nih.gov/pubmed/25234821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2014.09.012
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